A cytotoxic cardenolide and a saponin from the rhizomes of Tupistra chinensis

Fitoterapia. 2012 Dec;83(8):1489-93. doi: 10.1016/j.fitote.2012.08.015. Epub 2012 Aug 29.

Abstract

A new cardenolide tupichinolide (1) and a new steroidal saponin tupichinin A (2), together with seven known compounds, were isolated from the rhizomes of Tupistra chinensis. Their structures were established using spectroscopic analysis and chemical methods. Compound 1 was the first cardenolide isolated from Tupistra chinensis and exhibited potent cytotoxicity against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cardenolides / chemistry*
  • Cell Line, Tumor
  • Humans
  • Liliaceae / chemistry*
  • Molecular Structure
  • Rhizome / chemistry*
  • Saponins / chemistry*

Substances

  • Antineoplastic Agents, Phytogenic
  • Cardenolides
  • Saponins
  • tupichinolide