The correct setting of the ultrasound equipment is a prerequisite for a high quality of the ultrasound examination. Both the B-mode ultrasonography, as well as the Doppler technique offer interesting alternative settings that are often inadequately used. This brief summary of basic settings should help the practicing clinicians in everyday life and motivate them to deal with the «knobs» of the ultrasound device. Good practical help will provided by the «Sonocave» an event regularly organized at the annual ultrasonic training Congress in Davos, where recognized experts will answer such «Knobology»-questions and demonstrate the appropriate settings also practically.