A highly efficient green synthesis of N-alkyl 2-[(2-oxo-2-aryl ethyl) amino] benzamide derivatives from reaction of isatoic anhydride, primary amines and 2-bromoacethophenone

Comb Chem High Throughput Screen. 2012 Nov;15(9):745-8. doi: 10.2174/138620712803519716.

Abstract

N-alkyl 2-[(2-oxo-2-aryl ethyl)amino] benzamide derivatives have been synthesized in high yields. This involves three-component reaction of isatoic anhydride, primary amines in the presence of 2-bromoacethophenone derivatives. The reaction workup is simple and the products can be easily separated from the reaction mixture.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetophenones / chemistry*
  • Amines / chemistry*
  • Benzamides / chemical synthesis*
  • Benzamides / chemistry
  • Green Chemistry Technology*
  • Molecular Structure
  • Oxazines / chemistry*

Substances

  • 2-bromoacethophenone
  • Acetophenones
  • Amines
  • Benzamides
  • Oxazines
  • isatoic anhydride