Abstract
We describe two patients with otologic infections caused by Mycobacterium massiliense (M. abscessus subsp. bolletti) which were identified using erm(41) PCR, 23S rRNA, and rpoB gene sequence analysis. They were middle-aged adults with underlying otologic diseases and were treated successfully with clarithromycin-based combination regimens for 3 and 9 months, respectively.
MeSH terms
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Anti-Bacterial Agents / administration & dosage
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Clarithromycin / administration & dosage
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DNA, Bacterial / chemistry
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DNA, Bacterial / genetics
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DNA, Ribosomal / chemistry
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DNA, Ribosomal / genetics
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DNA-Directed RNA Polymerases / genetics
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Drug Therapy, Combination / methods
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Humans
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Male
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Mastoiditis / drug therapy
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Mastoiditis / microbiology*
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Methyltransferases / genetics
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Microbial Sensitivity Tests
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Middle Aged
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Mycobacterium / classification
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Mycobacterium / drug effects
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Mycobacterium / genetics
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Mycobacterium / isolation & purification*
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Mycobacterium Infections / diagnosis*
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Mycobacterium Infections / drug therapy
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Mycobacterium Infections / microbiology
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Otitis Media / drug therapy
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Otitis Media / microbiology*
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RNA, Ribosomal, 23S / genetics
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Sequence Analysis, DNA
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Treatment Outcome
Substances
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Anti-Bacterial Agents
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DNA, Bacterial
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DNA, Ribosomal
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RNA, Ribosomal, 23S
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Methyltransferases
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DNA-Directed RNA Polymerases
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RNA polymerase beta subunit
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Clarithromycin