Antimicrobial drug use and macrolide-resistant Streptococcus pyogenes, Belgium

Emerg Infect Dis. 2012 Sep;18(9):1515-8. doi: 10.3201/eid1809.120049.

Abstract

In Belgium, decreasing macrolide, lincosamide, streptogramins B, and tetracycline use during 1997-2007 correlated significantly with decreasing macrolide-resistant Streptococcus pyogenes during 1999-2009. Maintaining drug use below a critical threshold corresponded with low-level macrolide-resistant S. pyogenes and an increased number of erm(A)-harboring emm77 S. pyogenes with low fitness costs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Anti-Bacterial Agents / therapeutic use*
  • Bacterial Proteins / genetics
  • Belgium
  • Drug Resistance, Bacterial / genetics
  • Humans
  • Macrolides / pharmacology*
  • Macrolides / therapeutic use*
  • Membrane Proteins / genetics
  • Methyltransferases / genetics
  • Microbial Sensitivity Tests
  • Streptococcal Infections / drug therapy*
  • Streptococcus pyogenes / drug effects*
  • Streptococcus pyogenes / genetics

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Macrolides
  • MefA protein, Streptococcus
  • Membrane Proteins
  • Methyltransferases
  • ErmA protein, Bacteria