Abstract
Double-negative T cells (DNTCs; ie, CD3(+)CD4(-)CD8(-) T cells) play a role in limiting chronic immune activation. GB virus C (GBV-C) infection is associated with reduced T-cell activation in human immunodeficiency virus (HIV)-infected individuals. T-cell activation and DNTCs were measured in HIV-infected subjects with a nondetectable HIV load. GBV-C-viremic subjects had significantly reduced CD4(+) and CD8(+) T-cell activation (P = .003 and .034, respectively) and significantly increased DNTCs (P = .038), compared with nonviremic subjects. GBV-C load correlated with DNTC percentage (P = .004). Thus, GBV-C infection is associated with an increase in DNTCs, which may contribute to reduced immune activation during HIV infection.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Antiretroviral Therapy, Highly Active / methods*
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CD3 Complex / analysis
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CD4 Antigens / analysis
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CD4-Positive T-Lymphocytes / chemistry
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CD4-Positive T-Lymphocytes / immunology
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CD8 Antigens / analysis
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CD8-Positive T-Lymphocytes / chemistry
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CD8-Positive T-Lymphocytes / immunology
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GB virus C / isolation & purification*
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GB virus C / pathogenicity
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HIV Infections / complications*
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HIV Infections / drug therapy*
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HIV Infections / immunology
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Hepatitis, Viral, Human / complications*
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Hepatitis, Viral, Human / immunology
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Humans
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Lymphocyte Activation
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Male
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Middle Aged
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T-Lymphocyte Subsets / chemistry
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T-Lymphocyte Subsets / immunology*
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Viremia / complications*
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Viremia / immunology
Substances
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CD3 Complex
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CD4 Antigens
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CD8 Antigens