Unraveling stress-induced toxicity properties of graphene oxide and the underlying mechanism

Adv Mater. 2012 Oct 9;24(39):5391-7. doi: 10.1002/adma.201202678. Epub 2012 Aug 24.

Abstract

Graphene oxide shows stress-induced toxicity properties in vivo under different pathophysiological conditions. A dual-path chemical mechanism, involving the overproduction of hydroxyl radicals and the formation of oxidizing cytochrome c intermediates, is responsible for the toxicity properties.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Caenorhabditis elegans / drug effects*
  • Caenorhabditis elegans / metabolism
  • Cyclic N-Oxides / chemistry
  • Graphite / chemistry*
  • Graphite / toxicity*
  • Nanostructures / toxicity*
  • Oxidative Stress*
  • Oxides / chemistry*
  • Oxides / toxicity
  • Polyethylene Glycols / chemistry
  • Polylysine / chemistry

Substances

  • 5,5-dimethylpyrrolidin-2-one-1-oxide
  • Cyclic N-Oxides
  • Oxides
  • Polylysine
  • Polyethylene Glycols
  • Graphite