Abstract
Since cations have been reported as essential regulators of biofilm, we investigated the potential of the broad-spectrum antimicrobial and cation-chelator nitroxoline as an antibiofilm agent. Biofilm mass synthesis was reduced by up to 80% at sub-MIC nitroxoline concentrations in Pseudomonas aeruginosa, and structures formed were reticulate rather than compact. In preformed biofilms, viable cell counts were reduced by 4 logs at therapeutic concentrations. Complexation of iron and zinc was demonstrated to underlie nitroxoline's potent antibiofilm activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / metabolism
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Anti-Bacterial Agents / pharmacology*
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Biofilms / drug effects*
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Biofilms / growth & development
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Cations, Divalent
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Chelating Agents / metabolism
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Chelating Agents / pharmacology*
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Ciprofloxacin / pharmacology
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Colistin / pharmacology
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Iron / metabolism*
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Microbial Sensitivity Tests
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Nitroquinolines / metabolism
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Nitroquinolines / pharmacology*
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Plankton / drug effects
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Plankton / growth & development
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Pseudomonas aeruginosa / drug effects*
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Pseudomonas aeruginosa / growth & development
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Zinc / metabolism*
Substances
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Anti-Bacterial Agents
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Cations, Divalent
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Chelating Agents
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Nitroquinolines
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Ciprofloxacin
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nitroxoline
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Iron
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Zinc
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Colistin