Liver lipoma is an extremely rare tumor. Its nature and behavior is not well known since available information is based mostly on individual case reports. This report presents a case of liver lipoma mimicking malignant liver tumor. The patient was 72-year female with 5-year history of right upper abdominal quadrant pain. Diagnostic work-up revealed a large liver tumor mass, suspicious of malignancy. However, patohistological analysis found it to be lipoma. Because of extremely low incidence of liver lipoma, especially large ones, appropriate diagnostic work-up is very important for its differentiation from malignant tumors.