Abstract
A new vitamin D(2) analogue was synthesized using the Julia-Kocienski olefination. It has antiproliferative effects on cell lines from squamous cell carcinomas of colon and head and neck, but is also as hypercalcaemic as calcitriol in vivo.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Calcium / blood
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Ergocalciferols / chemical synthesis*
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Ergocalciferols / chemistry
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Ergocalciferols / pharmacology*
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HCT116 Cells
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Humans
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Mice
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Molecular Structure
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Ergocalciferols
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Calcium