Synthesis and biological evaluation of a new vitamin D2 analogue

Bioorg Med Chem Lett. 2012 Oct 1;22(19):6276-9. doi: 10.1016/j.bmcl.2012.07.095. Epub 2012 Aug 7.

Abstract

A new vitamin D(2) analogue was synthesized using the Julia-Kocienski olefination. It has antiproliferative effects on cell lines from squamous cell carcinomas of colon and head and neck, but is also as hypercalcaemic as calcitriol in vivo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Calcium / blood
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor
  • Ergocalciferols / chemical synthesis*
  • Ergocalciferols / chemistry
  • Ergocalciferols / pharmacology*
  • HCT116 Cells
  • Humans
  • Mice
  • Molecular Structure
  • Structure-Activity Relationship

Substances

  • Antineoplastic Agents
  • Ergocalciferols
  • Calcium