Abstract
A new cubitane diterpenoid, crassalone A (1), was isolated from the marine soft coral Sinularia crassa. The structure was determined by extensive spectroscopic analyses. Compound 1 is not cytotoxic (IC₅₀ > 20 μg/mL) toward the four human cancer cell lines tested (HL60, MDA-MB-231, HCT-116 and DLD-1).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenocarcinoma / drug therapy
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Animals
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Anthozoa / chemistry*
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Breast Neoplasms / drug therapy
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Cell Line, Tumor
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Colonic Neoplasms / drug therapy
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Colorectal Neoplasms / drug therapy
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Diterpenes / chemistry*
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Diterpenes / isolation & purification
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Diterpenes / pharmacology*
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Drug Screening Assays, Antitumor*
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Humans
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Leukemia, Promyelocytic, Acute / drug therapy
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Molecular Structure
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Neoplasms / drug therapy*