A new cubitane diterpenoid from the soft coral Sinularia crassa

Molecules. 2012 Aug 24;17(9):10072-8. doi: 10.3390/molecules170910072.

Abstract

A new cubitane diterpenoid, crassalone A (1), was isolated from the marine soft coral Sinularia crassa. The structure was determined by extensive spectroscopic analyses. Compound 1 is not cytotoxic (IC₅₀ > 20 μg/mL) toward the four human cancer cell lines tested (HL60, MDA-MB-231, HCT-116 and DLD-1).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / drug therapy
  • Animals
  • Anthozoa / chemistry*
  • Breast Neoplasms / drug therapy
  • Cell Line, Tumor
  • Colonic Neoplasms / drug therapy
  • Colorectal Neoplasms / drug therapy
  • Diterpenes / chemistry*
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology*
  • Drug Screening Assays, Antitumor*
  • Humans
  • Leukemia, Promyelocytic, Acute / drug therapy
  • Molecular Structure
  • Neoplasms / drug therapy*

Substances

  • Diterpenes