A nanoscale graphene oxide-peptide biosensor for real-time specific biomarker detection on the cell surface

Chem Commun (Camb). 2012 Oct 9;48(78):9768-70. doi: 10.1039/c2cc31974h.

Abstract

A nanoscale RGD-pyrene-graphene oxide (GO) biosensor was prepared for real-time in situ detection of a cancer cell surface marker, integrin αvβ3. This nanoscale GO-based biosensor is simple, robust, sensitive and of high selectivity. It can also be adapted to other cancer cell surface marker evaluation systems.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural

MeSH terms

  • Biomarkers / analysis
  • Biosensing Techniques*
  • Breast Neoplasms / chemistry*
  • Breast Neoplasms / pathology
  • Graphite / chemistry*
  • Humans
  • Integrin alphaVbeta3 / analysis*
  • MCF-7 Cells
  • Nanostructures / chemistry*
  • Oligopeptides / chemistry*
  • Oxides / chemistry*
  • Pyrenes / chemistry
  • Surface Properties
  • Time Factors
  • Tumor Cells, Cultured

Substances

  • Biomarkers
  • Integrin alphaVbeta3
  • Oligopeptides
  • Oxides
  • Pyrenes
  • Graphite
  • arginyl-glycyl-aspartic acid
  • pyrene