Abstract
There is no FDA-approved vaccine for the potent plant toxin ricin. We have developed a recombinant ricin vaccine, RiVax. Without adjuvant it is safe and immunogenic in mice, rabbits, and humans. Based on our studies in mice, we now report the results of a small clinical trial with Alhydrogel-adsorbed RiVax.
Publication types
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Clinical Trial, Phase I
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adsorption
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Adult
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Aluminum Hydroxide
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Antibodies / immunology
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Antibody Formation
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Female
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Humans
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Male
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Pilot Projects*
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Ricin / antagonists & inhibitors
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Ricin / immunology*
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Vaccines* / administration & dosage
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Vaccines* / adverse effects
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Vaccines* / immunology
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Vaccines, Synthetic / administration & dosage
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Vaccines, Synthetic / adverse effects
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Vaccines, Synthetic / immunology
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Young Adult
Substances
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Antibodies
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RiVax
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Vaccines
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Vaccines, Synthetic
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Aluminum Hydroxide
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Ricin