We tested the efficacy of the Healthy Workplace programme for metabolic syndrome. A total of 226 workers with metabolic syndrome from 12 companies enrolled in the study and completed baseline and 6-month follow-up. The Healthy Workplace programme consisted of a 4-week structured education module, telephone counselling, mobile phone messages (SMS) and email messages in the ensuing 6 months. The main outcome measures of the pre-post study were waist circumference, high-density lipoprotein (HDL) cholesterol, triglycerides, blood pressure (BP) and glucose levels. At follow-up, waist circumference and diastolic BP were significantly reduced compared to baseline. Triglyceride and fasting glucose levels improved significantly 6 months after the study. At 6-month follow-up, manifest risk factors for metabolic syndrome had disappeared in 9% of the participants. The integrated Healthy Workplace programme encouraged workers to improve self-care behaviours.