Synthesis of hetero-polymer functionalized nanocarriers by combining surface-initiated ATRP and RAFT polymerization

Small. 2012 Dec 7;8(23):3579-83. doi: 10.1002/smll.201201397. Epub 2012 Aug 22.

Abstract

Smart nanocarriers are created based on a bi-functional hetero-initiator for RAFT and ATRP technique, bi-functionalizing mesoporous silica nanoparticles with two polymer types. The pH-dependent behavior of PDEAEMA as the gatekeeper polymer is verified by electrokinetic measurements and a controlled release behavior is demonstrated using doxorubicin as the drug.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Doxorubicin / chemistry
  • Doxorubicin / pharmacology
  • Hydrogen-Ion Concentration
  • Kinetics
  • Methacrylates / chemistry
  • Nanoparticles / chemistry*
  • Nucleosides / chemistry
  • Nylons / chemistry
  • Polymerization
  • Polymers / chemical synthesis*
  • Pyrazoles / chemistry
  • Silicon Dioxide / chemistry
  • Spectroscopy, Fourier Transform Infrared
  • Surface Properties

Substances

  • Methacrylates
  • Nucleosides
  • Nylons
  • Polymers
  • Pyrazoles
  • poly(2-(diethylamino)ethyl methacrylate)
  • Silicon Dioxide
  • Doxorubicin
  • 4-amino-3-(2,3,5-tri-O-benzyl-beta-ribofuranosyl)-5-pyrazole carbonitrile