Abstract
Smart nanocarriers are created based on a bi-functional hetero-initiator for RAFT and ATRP technique, bi-functionalizing mesoporous silica nanoparticles with two polymer types. The pH-dependent behavior of PDEAEMA as the gatekeeper polymer is verified by electrokinetic measurements and a controlled release behavior is demonstrated using doxorubicin as the drug.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Doxorubicin / chemistry
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Doxorubicin / pharmacology
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Hydrogen-Ion Concentration
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Kinetics
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Methacrylates / chemistry
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Nanoparticles / chemistry*
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Nucleosides / chemistry
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Nylons / chemistry
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Polymerization
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Polymers / chemical synthesis*
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Pyrazoles / chemistry
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Silicon Dioxide / chemistry
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Spectroscopy, Fourier Transform Infrared
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Surface Properties
Substances
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Methacrylates
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Nucleosides
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Nylons
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Polymers
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Pyrazoles
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poly(2-(diethylamino)ethyl methacrylate)
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Silicon Dioxide
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Doxorubicin
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4-amino-3-(2,3,5-tri-O-benzyl-beta-ribofuranosyl)-5-pyrazole carbonitrile