This study aimed to identify the impact of the main treatments for migraine on the quality of life (QOL) as affected people and the instruments used to assess the QOL. It consists of an integrative review of the literature, in which the databases PubMed, BIREME and The Cochrane Library were used, considering articles from 2000 to 2009. We selected 42 articles for analysis, which were fully read. The articles were classified into three categories: pharmacological treatments for the crisis, prophylactic drug treatments and alternative treatments for migraine. In most studies, the tools used to assess QOL were validated and the most commonly used were the Medical Outcomes Study Questionnaire 36 - Item Short Form Health Survey (SF 36), the Migraine-Specific Quality of Life Questionnaire (MSQ) and the Migraine Disability Assessment (MIDAS). We conclude that, in general, the treatments seem to be positive on the QOL of individuals with migraine.