Susceptibility of non-enveloped DNA- and RNA-type viruses to photodynamic inactivation

Photochem Photobiol Sci. 2012 Oct;11(10):1520-3. doi: 10.1039/c2pp25156f.

Abstract

The comparative susceptibility of DNA- and RNA-type viruses to photodynamic inactivation has not yet been clearly addressed. In this study the effect of the tricationic porphyrin Tri-Py(+)-Me-PF on the inactivation of four DNA and three RNA non-enveloped phages was compared. The results obtained show that the photodynamic efficiency varied with the phage type, the RNA-type phages being much more easily photoinactivated than the DNA-type ones.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacteria / virology
  • Bacteriophages / drug effects
  • Bacteriophages / physiology*
  • Bacteriophages / radiation effects
  • DNA Viruses / drug effects
  • DNA Viruses / physiology*
  • DNA Viruses / radiation effects
  • Dimethyl Sulfoxide / chemistry
  • Light
  • Magnetic Resonance Spectroscopy
  • Photolysis*
  • Photosensitizing Agents / chemical synthesis
  • Photosensitizing Agents / pharmacology*
  • Porphyrins / chemical synthesis
  • Porphyrins / pharmacology*
  • RNA Viruses / drug effects
  • RNA Viruses / physiology*
  • RNA Viruses / radiation effects
  • Species Specificity

Substances

  • 5,10,15-tris(1-methylpyridinium-4-yl)-20-(pentafluorophenyl)porphyrin triiodide
  • Photosensitizing Agents
  • Porphyrins
  • Dimethyl Sulfoxide