Abstract
The comparative susceptibility of DNA- and RNA-type viruses to photodynamic inactivation has not yet been clearly addressed. In this study the effect of the tricationic porphyrin Tri-Py(+)-Me-PF on the inactivation of four DNA and three RNA non-enveloped phages was compared. The results obtained show that the photodynamic efficiency varied with the phage type, the RNA-type phages being much more easily photoinactivated than the DNA-type ones.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacteria / virology
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Bacteriophages / drug effects
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Bacteriophages / physiology*
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Bacteriophages / radiation effects
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DNA Viruses / drug effects
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DNA Viruses / physiology*
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DNA Viruses / radiation effects
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Dimethyl Sulfoxide / chemistry
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Light
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Magnetic Resonance Spectroscopy
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Photolysis*
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Photosensitizing Agents / chemical synthesis
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Photosensitizing Agents / pharmacology*
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Porphyrins / chemical synthesis
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Porphyrins / pharmacology*
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RNA Viruses / drug effects
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RNA Viruses / physiology*
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RNA Viruses / radiation effects
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Species Specificity
Substances
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5,10,15-tris(1-methylpyridinium-4-yl)-20-(pentafluorophenyl)porphyrin triiodide
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Photosensitizing Agents
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Porphyrins
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Dimethyl Sulfoxide