An alternative one-pot gold-catalyzed approach to the assembly of 11H-indolo[3,2-c]quinolines

Org Biomol Chem. 2012 Oct 14;10(38):7801-8. doi: 10.1039/c2ob26380g.

Abstract

A new one-pot approach was developed to construct the 11H-indolo[3,2-c]quinoline scaffold through a gold-catalysed reaction of 2-[(2-aminophenyl)ethynyl]phenylamine derivatives with aldehydes. The broad scope and the high regioselectivity of this new protocol as well as the mild and neutral reaction conditions make it a viable alternative to the previously reported procedures.

MeSH terms

  • Catalysis
  • Gold / chemistry*
  • Indoles / chemical synthesis*
  • Indoles / chemistry
  • Molecular Structure
  • Organogold Compounds / chemistry*
  • Quinolines / chemical synthesis*
  • Quinolines / chemistry
  • Stereoisomerism

Substances

  • Indoles
  • Organogold Compounds
  • Quinolines
  • Gold