miRNA and tropism of human parvovirus B19

Olga Berillo; Vladimir Khailenko; Anatoly Ivashchenko; Lior Perlmuter-Shoshany; Alexander Bolshoy

doi:10.1016/j.compbiolchem.2012.06.002

miRNA and tropism of human parvovirus B19

Comput Biol Chem. 2012 Oct:40:1-6. doi: 10.1016/j.compbiolchem.2012.06.002. Epub 2012 Jul 31.

Authors

Olga Berillo¹, Vladimir Khailenko, Anatoly Ivashchenko, Lior Perlmuter-Shoshany, Alexander Bolshoy

Affiliation

¹ Department of Biotechnology, Al-Farabi Kazakh National University, Al-Farabi prospect, 71, Almaty 050038, Kazakhstan.

PMID: 22902951
DOI: 10.1016/j.compbiolchem.2012.06.002

Abstract

Parvovirus B19 has an extreme tropism for human erythroid progenitors. Here we propose the hypothesis explaining the tropism of human parvovirus B19. Our speculations are based on experimental results related to the capsid proteins VP1 and VP2. These proteins were not detectable in nonpermissive cells in course of these experiments, although the corresponding mRNAs were synthesized. Our interpretation of these results is an inhibition of translation in nonpermissive cells by human miRNAs. We bring support to our hypothesis and propose detailed experimental procedure to test it.

MeSH terms

Amino Acid Sequence
Computational Biology
Host Specificity
Humans
Introns
MicroRNAs / genetics
MicroRNAs / metabolism*
Molecular Sequence Data
Parvovirus B19, Human / drug effects
Parvovirus B19, Human / genetics*
Parvovirus B19, Human / growth & development*
RNA, Messenger / antagonists & inhibitors*
RNA, Messenger / genetics

Substances

MicroRNAs
RNA, Messenger