The bioassay-guided isolation of growth inhibitors of adult T-cell leukemia (ATL), from the Jamaican plant Hyptis verticillata, and NMR characterization of hyptoside

Toshiyuki Hamada; Yohann White; Mitsuyoshi Nakashima; Yusuke Oiso; Masaki J Fijita; Hiroaki Okamura; Tetsuo Iwagawa; Naomichi Arima

doi:10.3390/molecules17089931

The bioassay-guided isolation of growth inhibitors of adult T-cell leukemia (ATL), from the Jamaican plant Hyptis verticillata, and NMR characterization of hyptoside

Molecules. 2012 Aug 17;17(8):9931-8. doi: 10.3390/molecules17089931.

Authors

Toshiyuki Hamada¹, Yohann White, Mitsuyoshi Nakashima, Yusuke Oiso, Masaki J Fijita, Hiroaki Okamura, Tetsuo Iwagawa, Naomichi Arima

Affiliation

¹ Graduate School of Science and Engineering, Kagoshima University, 1-21-35 Korimoto, Kagoshima 890-0065, Japan. thamada@sci.kagoshima-u.ac.jp

Abstract

Through bioassay-guided isolation, five compounds with growth inhibitory activity on S1T, an adult T-cell leukemia (ATL) cell line, were isolated from the crude methanol extract of the aerial parts of Hyptis verticillata.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry*
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology
Apoptosis / drug effects
Cell Line, Tumor
Drug Screening Assays, Antitumor
Growth Inhibitors / chemistry*
Growth Inhibitors / isolation & purification
Growth Inhibitors / pharmacology
Humans
Hyptis / chemistry*
Inhibitory Concentration 50
Leukemia-Lymphoma, Adult T-Cell
Nuclear Magnetic Resonance, Biomolecular
Plant Components, Aerial / chemistry
Plant Extracts / chemistry*

Substances

Antineoplastic Agents
Growth Inhibitors
Plant Extracts