Abstract
A series of novel N-acyl substituted quinolin-2(1H)-one derivatives were synthesized and screened in vitro for their antibacterial and antifungal activities by disc diffusion method. All the compounds exhibited moderate to good antimicrobial activities, some of these compounds displayed comparable or better antibacterial or antifungal activities against some tested strains compared to the reference drugs Streptomycin and Fluconazole.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology*
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Bacteria / drug effects*
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Dose-Response Relationship, Drug
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Fungi / drug effects*
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Microbial Sensitivity Tests
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Molecular Structure
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Quinolones / chemical synthesis
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Quinolones / chemistry
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Quinolones / pharmacology*
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Quinolones