Abstract
An efficient synthesis of racemic and both enantiomeric forms of heteroaryl substituted γ- and δ-lactone derivatives derived from allyl and homoallyl alcohol backbones has been accomplished via ring closing metathesis reaction. 2-Heteroaryl substituted allyl and homoallyl alcohols have been efficiently resolved through enzymatic method with high ee (97-99%) and known stereochemistry. Antimicrobial and antioxidant activities of target lactones were evaluated.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Alcohols / chemistry
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Antifungal Agents / chemical synthesis
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology*
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Antioxidants / chemical synthesis*
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Antioxidants / chemistry
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Antioxidants / pharmacology*
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Bacteria / drug effects*
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Dose-Response Relationship, Drug
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Fungi / drug effects*
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Lactones / chemical synthesis
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Lactones / chemistry
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Lactones / pharmacology*
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Microbial Sensitivity Tests
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Molecular Structure
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Oxidation-Reduction
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Alcohols
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Anti-Bacterial Agents
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Antifungal Agents
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Antioxidants
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Lactones