Synthesis and antifungal activity of 1-thia-4b-aza-cyclopenta[b]fluorene-4,10-diones

Bioorg Med Chem Lett. 2012 Sep 15;22(18):5777-9. doi: 10.1016/j.bmcl.2012.07.097. Epub 2012 Aug 5.

Abstract

1-Thia-4b-aza-cyclopenta[b]fluorene-4,10-diones were synthesized and tested for in vitro antifungal activity against two pathogenic strains of fungi. Among them tested, many compounds showed good antifungal activity. The results suggest that 1-thia-4b-aza-cyclopenta[b]fluorene-4,10-diones would be antifungal agents.

MeSH terms

  • Antifungal Agents / chemical synthesis*
  • Antifungal Agents / chemistry
  • Antifungal Agents / pharmacology*
  • Dose-Response Relationship, Drug
  • Fluorenes / chemical synthesis
  • Fluorenes / chemistry
  • Fluorenes / pharmacology*
  • Fungi / drug effects*
  • Fungi / growth & development
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Stereoisomerism
  • Structure-Activity Relationship

Substances

  • 1-thia-4b-aza-cyclopenta(b)fluorene-4,10-dione
  • Antifungal Agents
  • Fluorenes