RETRACTED: Cardiac-specific overexpression of catalase attenuates lipopolysaccharide-induced myocardial contractile dysfunction: Role of autophagy

Free Radic Biol Med. 2012 Sep 15;53(6):1327-1338. doi: 10.1016/j.freeradbiomed.2012.07.084. Epub 2012 Aug 5.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief. After an institutional investigation into the work of Dr. Jun Ren, University of Wyoming subsequently conducted an examination of other selected publications of Dr. Ren's under the direction of the HHS Office of Research Integrity. Based on the findings of this examination, the University of Wyoming recommended this article be retracted due to concerns regarding data irregularities inconsistent with published conclusions. Specifically, University of Wyoming found evidence of data irregularities and image reuse in Figure 2 that significantly affect the results and conclusions reported in the manuscript.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Retracted Publication

MeSH terms

  • Animals
  • Apoptosis
  • Autophagy*
  • Calcium / metabolism
  • Calcium Signaling
  • Catalase / genetics
  • Catalase / metabolism*
  • Endotoxemia / chemically induced
  • Endotoxemia / enzymology
  • Endotoxemia / physiopathology*
  • Gene Expression
  • Heart Rate
  • Heart Ventricles / immunology
  • Heart Ventricles / pathology
  • Heart Ventricles / physiopathology
  • Kaplan-Meier Estimate
  • Lipopolysaccharides
  • MAP Kinase Signaling System
  • Male
  • Mice
  • Mice, Transgenic
  • Myocardial Contraction*
  • Myocardium / enzymology*
  • Myocardium / immunology
  • Myocardium / pathology
  • Myocytes, Cardiac / enzymology
  • Myocytes, Cardiac / immunology
  • Myocytes, Cardiac / physiology
  • Oxidative Stress
  • Reactive Oxygen Species / metabolism
  • Tumor Necrosis Factor-alpha / genetics
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Lipopolysaccharides
  • Reactive Oxygen Species
  • Tumor Necrosis Factor-alpha
  • Catalase
  • Calcium