Abstract
This manuscript concludes the Structure Activity Relationship (SAR) on the pyridazinone scaffold and identifies a compound with subnanomolar p38α activity and 24h coverage in the rat arthritis efficacy model.
Copyright © 2012 Elsevier Ltd. All rights reserved.
MeSH terms
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Animals
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Dogs
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Dose-Response Relationship, Drug
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Haplorhini
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Humans
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Mitogen-Activated Protein Kinase 14 / antagonists & inhibitors*
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Mitogen-Activated Protein Kinase 14 / metabolism
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Molecular Structure
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Protein Kinase Inhibitors / administration & dosage
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Protein Kinase Inhibitors / chemical synthesis*
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Protein Kinase Inhibitors / pharmacology*
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Pyridazines / administration & dosage
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Pyridazines / chemical synthesis*
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Pyridazines / pharmacology*
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Pyridines / administration & dosage
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Pyridines / chemical synthesis*
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Pyridines / pharmacology*
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Rats
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Structure-Activity Relationship
Substances
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Protein Kinase Inhibitors
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Pyridazines
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Pyridines
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pyridopyridazin-6-one
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Mitogen-Activated Protein Kinase 14