High-dose monoclonal antibodies via the subcutaneous route: challenges and technical solutions, an industry perspective

Ther Deliv. 2012 Jul;3(7):889-900. doi: 10.4155/tde.12.68.

Abstract

This review summarizes the various challenges in product development involved in subcutaneous administration of high-dose monoclonal antibodies and attempts to provide an industry perspective of some of the available technologies and potential avenues to overcome these challenges.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antibodies, Monoclonal / administration & dosage*
  • Antibodies, Monoclonal / chemistry
  • Chemistry, Pharmaceutical
  • Drug Delivery Systems
  • Humans
  • Immunotherapy / methods*
  • Infusions, Subcutaneous
  • Injections, Subcutaneous
  • Nanotechnology
  • Protein Denaturation
  • Technology, Pharmaceutical / methods
  • Viscosity

Substances

  • Antibodies, Monoclonal