Abstract
This review summarizes the various challenges in product development involved in subcutaneous administration of high-dose monoclonal antibodies and attempts to provide an industry perspective of some of the available technologies and potential avenues to overcome these challenges.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Antibodies, Monoclonal / administration & dosage*
-
Antibodies, Monoclonal / chemistry
-
Chemistry, Pharmaceutical
-
Drug Delivery Systems
-
Humans
-
Immunotherapy / methods*
-
Infusions, Subcutaneous
-
Injections, Subcutaneous
-
Nanotechnology
-
Protein Denaturation
-
Technology, Pharmaceutical / methods
-
Viscosity