Abstract
Simian immunodeficiency virus (SIV) infection of natural hosts is characterized by nonpathogenic chronic viremia, maintenance of gastrointestinal epithelial barrier integrity, and low numbers of target cells. Assessment of cell-associated virus load in T cell subsets in multiple anatomic compartments of chronically SIV-infected sabeus African green monkeys (AGMs) revealed that gastrointestinal memory CD4(+) T lymphocytes are a major source of cell-associated virus and a significant contributor to SIV viremia in AGMs.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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CD4 Antigens / genetics
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CD4-Positive T-Lymphocytes / immunology
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CD4-Positive T-Lymphocytes / virology*
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Chlorocebus aethiops
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Gastrointestinal Tract / immunology*
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Gastrointestinal Tract / virology*
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Immunologic Memory*
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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Simian Acquired Immunodeficiency Syndrome / immunology*
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Simian Acquired Immunodeficiency Syndrome / virology*
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Simian Immunodeficiency Virus / immunology
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Simian Immunodeficiency Virus / physiology*
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Viral Load
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Viremia
Substances
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CD4 Antigens
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RNA, Messenger