Poly[2-(methacryloyloxy)ethylphosphorylcholine]-coated iron oxide nanoparticles: synthesis, colloidal stability and evaluation for stem cell labelling

Chem Commun (Camb). 2012 Sep 28;48(75):9373-5. doi: 10.1039/c2cc34420c. Epub 2012 Aug 15.

Abstract

Poly[2-(methacryloyloxy)ethylphosphorylcholine]-coated SPIONs were prepared through ATRP and amidation coupling reactions. The coated SPIONs exhibited high stability and re-dispersability in phosphate buffered saline and uptake in a stem cell line, with high T(2) relaxivity.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Buffers
  • Chemistry Techniques, Synthetic
  • Colloids
  • Drug Stability
  • Ferric Compounds / chemical synthesis
  • Ferric Compounds / chemistry*
  • Ferric Compounds / metabolism*
  • Methacrylates / chemistry*
  • Mice
  • Nanoparticles / chemistry*
  • Phosphorylcholine / analogs & derivatives*
  • Phosphorylcholine / chemistry
  • Polymethacrylic Acids
  • Staining and Labeling
  • Stem Cells / metabolism*

Substances

  • Buffers
  • Colloids
  • Ferric Compounds
  • Methacrylates
  • Polymethacrylic Acids
  • poly(2-methacryloyloxyethyl-phosphorylcholine)
  • Phosphorylcholine
  • ferric oxide