Do transcription factories and TOP2B provide a recipe for chromosome translocations in therapy-related leukemia?

Cell Cycle. 2012 Sep 1;11(17):3143-4. doi: 10.4161/cc.21477. Epub 2012 Aug 16.

Abstract

Comment on: Cowell IG, et al. Proc Natl Acad Sci USA 2012; 109:8989-94.

Publication types

  • Editorial

MeSH terms

  • Anthracyclines / metabolism
  • Anthracyclines / toxicity
  • DNA Breaks, Double-Stranded / drug effects
  • DNA Topoisomerases, Type II / metabolism*
  • DNA-Binding Proteins / metabolism*
  • Epirubicin / metabolism
  • Epirubicin / toxicity
  • Etoposide / metabolism
  • Etoposide / toxicity
  • Humans
  • Leukemia / genetics*
  • Mitoxantrone / metabolism
  • Mitoxantrone / toxicity
  • Models, Genetic*
  • Neoplasms, Second Primary / genetics*
  • Poly-ADP-Ribose Binding Proteins
  • Translocation, Genetic / drug effects*
  • Translocation, Genetic / genetics

Substances

  • Anthracyclines
  • DNA-Binding Proteins
  • Poly-ADP-Ribose Binding Proteins
  • Epirubicin
  • Etoposide
  • Mitoxantrone
  • DNA Topoisomerases, Type II
  • TOP2B protein, human