Abstract
Pulsatile release: When a high-frequency magnetic field is applied, heat will be generated by coupling to the iron oxide nanoparticles encapsulated in the shells of PLGA hollow microspheres. As the temperature approaches the T(g) of PLGA, the polymer chains become more mobile, subsequently increasing the free volume of PLGA matrix and significantly enhancing the diffusion of drug molecules.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry*
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Chemistry, Pharmaceutical
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Doxorubicin / chemistry*
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Drug Carriers
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Ferric Compounds / chemistry
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Lactic Acid / chemistry*
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Magnetic Fields
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Microspheres*
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Nanoparticles
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Particle Size
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Permeability
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Polyglycolic Acid / chemistry*
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Polylactic Acid-Polyglycolic Acid Copolymer
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Pulsatile Flow
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Temperature
Substances
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Antineoplastic Agents
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Drug Carriers
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Ferric Compounds
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ferric oxide
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Polylactic Acid-Polyglycolic Acid Copolymer
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Polyglycolic Acid
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Lactic Acid
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Doxorubicin