Infertility is defined as the inability to conceive in a given pair, despite regular sexual intercourse for at least 12 months. In 2004, the World Health Organization has recognized infertility as a social disease. Nowadays, the problem of infertility, meets 1 to 6 pairs, which affects approximately 13-15% of couples the world's population. In Poland, this problem affects between 700 thousand to a million pairs. Male infertility may arise from the use of pharmacotherapy and adverse drug reactions. This publication provides an overview of the type of drugs impairing function of male genitalia and to discuss mechanisms for their action on the process of spermatogenesis.