Cephalosporin-3'-diazeniumdiolates: targeted NO-donor prodrugs for dispersing bacterial biofilms

Angew Chem Int Ed Engl. 2012 Sep 3;51(36):9057-60. doi: 10.1002/anie.201202414. Epub 2012 Aug 13.

Abstract

Just say NO to biofilms: NO-donors are used to disperse a bacterial biofilm so that co-administered antibiotics will kill the more susceptible unattached cells. The chemically stable cephalosporin-3'-diazeniumdiolate NO-donor prodrug is activated by bacterial β-lactamases and facilitates this two-step biofilm erradication.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Biofilms / drug effects*
  • Cephalosporins / chemistry*
  • Nitric Oxide Donors / chemistry
  • Nitric Oxide Donors / pharmacology
  • Prodrugs / chemistry*
  • Prodrugs / pharmacology
  • Pseudomonas aeruginosa / physiology*
  • beta-Lactamases / metabolism

Substances

  • Anti-Bacterial Agents
  • Cephalosporins
  • Nitric Oxide Donors
  • Prodrugs
  • beta-Lactamases