Metastatic neuroendocrine carcinoma presenting as a "Superscan" on 68Ga-DOTANOC somatostatin receptor PET/CT

Clin Nucl Med. 2012 Sep;37(9):892-4. doi: 10.1097/RLU.0b013e31825b1e6c.

Abstract

PET/CT imaging using Ga-labeled somatostatin analogs has become a popular noninvasive diagnostic modality in the workup of patients with neuroendocrine tumors. A 65-year-old man with pancreatic neuroendocrine tumor with confirmed liver metastases on conventional imaging underwent restaging Ga-DOTANOC PET/CT to monitor response to cold octreotide therapy. Previous PET/CT had shown presence of multiple liver and skeletal metastases along with a primary pancreatic tumor showing intense tracer uptake. The present PET/CT study showed an increase in number and uptake of the metastatic lesions suggestive of progressive disease resulting in the appearance of a superscan.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Carcinoma, Neuroendocrine / diagnostic imaging*
  • Carcinoma, Neuroendocrine / pathology*
  • Humans
  • Male
  • Multimodal Imaging*
  • Neoplasm Metastasis
  • Organometallic Compounds*
  • Positron-Emission Tomography*
  • Receptors, Somatostatin / metabolism*
  • Tomography, X-Ray Computed*

Substances

  • 68Ga-DOTANOC
  • Organometallic Compounds
  • Receptors, Somatostatin