Selective multicolour imaging of zebrafish muscle fibres by using fluorescent organic nanoparticles

Abstract

Glowing fish: Fluorescent organic nanoparticles (FONs) were prepared from pyrene-containing guanine analogues. FONs are able to penetrate into human cells and zebrafish embryos; they are nontoxic, biocompatible and were found to be specific for muscular tissues. This study demonstrates for the first time the possibility of using FONs for in vivo, whole-body, fluorescence imaging of zebrafish.