Distribution of human recombinant interferon-alpha 2 in rat plasma, liver, and experimental liver metastases

V Bocci; F Carraro; A Naldini; P P Cagol; E M Pasqual; C Prevaldi; D Casara

Distribution of human recombinant interferon-alpha 2 in rat plasma, liver, and experimental liver metastases

Mol Biother. 1990 Dec;2(4):233-4.

Authors

V Bocci¹, F Carraro, A Naldini, P P Cagol, E M Pasqual, C Prevaldi, D Casara

Affiliation

¹ Institute of General Physiology, University of Siena, Italy.

PMID: 2288723

Abstract

It has been ascertained that one of several possible reasons for negligible interferon activity in solid tumors, namely, hepatic metastases induced in rats after intraportal injection of Walker carcinoma 256 cells, is the significantly lower levels of interferon in the interstitial fluid of metastases in comparison to normal liver and plasma.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Humans
Interferon alpha-2
Interferon-alpha / blood
Interferon-alpha / metabolism*
Liver Neoplasms / metabolism*
Liver Neoplasms / secondary
Male
Rats
Rats, Inbred Strains
Recombinant Proteins / metabolism

Substances

Interferon alpha-2
Interferon-alpha
Recombinant Proteins