Stem cell research has become one of the hot points in the medical field, including wound healing, repairing, or regeneration medicine, because stem cells have the characteristics of self-renewal and differentiating into multiple types of total specialized cells of the body. The researchers involved in stem cell research hope that they can use this skill to one day create tissues or even organs instead of treating damaged tissues or organs in severe injury or in terminal-stage diseases, thus prolonging the life of patients and improving their quality of the life. But it is still a long way ahead with many difficulties to overcome to realize this dream. In this article, the authors discuss some problems in this special field.