Purpose: To explore whether the renal function parameters were associated with urinary nickel(Ni) and chromium(Cr) in patients undergoing dental restoration of nickel-chromium(Ni-Cr).
Methods: Seven hundred and ninety-five Ni-Cr alloy consumers were investigated by the questionnaire and the biological examination of renal function. The correlations between renal function parameters and urinary Ni(or Cr) were determined by Student's t test, one-way ANOVA, and Logistic regression analysis using SPSS12.0 software package.
Results: After dividing all subjects into three groups with equal sample size by urinary Ni (<38,38-90, ≥ 90μg/mol crea.), the middle group (38-90μg/mol crea.) had a significantly higher serum creatinine and estimated glomerular filtration rate (eGFR) compared to the other two groups, and there was no significant difference in other serum or urinary parameters of renal function. After dividing all subjects into three groups by urinary Cr(<38,38-88, and ≥ 90μg/mol crea.), no change was found in serum parameters, but urinary N-acetyl-β-D-glucosaminidase (UNAG) and retinol-binding protein (URBP) showed negative association with urinary Cr. The prevalence of either abnormal eGFR and abnormal urine parameters of renal function did not show significant change between different dose of urinary Ni or Cr.
Conclusions: No association of renal changes with urinary excretion of Ni and Cr was found in patients undergoing dental restoration of Ni-Cr alloy.