Finally, polyubiquitinated PCNA gets recognized

Michelle K Zeman; Karlene A Cimprich

doi:10.1016/j.molcel.2012.07.024

Finally, polyubiquitinated PCNA gets recognized

Mol Cell. 2012 Aug 10;47(3):333-4. doi: 10.1016/j.molcel.2012.07.024.

Authors

Michelle K Zeman¹, Karlene A Cimprich

Affiliation

¹ Department of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA.

PMID: 22883622
DOI: 10.1016/j.molcel.2012.07.024

Abstract

Studies from Ciccia et al. (2012) and Yuan et al. (2012) in this issue of Molecular Cell, together with Weston et al. (2012), reveal that the translocase ZRANB3/AH2 can recognize K63-linked polyubiquitinated PCNA and plays an important role in restarting stalled replication forks.

Publication types

Comment

Grants and funding

R01 ES016486/ES/NIEHS NIH HHS/United States