TXNIP switches tracks toward a terminal UPR

Tracy G Anthony; Ronald C Wek

doi:10.1016/j.cmet.2012.07.012

TXNIP switches tracks toward a terminal UPR

Cell Metab. 2012 Aug 8;16(2):135-7. doi: 10.1016/j.cmet.2012.07.012.

Authors

Tracy G Anthony¹, Ronald C Wek

Affiliation

¹ Department of Nutritional Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA.

PMID: 22883225
DOI: 10.1016/j.cmet.2012.07.012

Abstract

During the progression of diabetes, crosstalk between ER stress and inflammation controls islet cell fate. In this issue, Lerner et al. (2012) and Oslowski et al. (2012) discover that thioredoxin-interacting protein (TXNIP) is a regulatory switch connecting the terminal unfolded protein response (UPR) and NLRP3 inflammasome to mediate β cell death.

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