Purpose: Epidemiologic evidence demonstrates that heavy drinking increases the risk of stroke. However, whether recent heavy drinking affects the incidence of acute stroke in nonalcoholic individuals with the variant allele ALDH2*2 has not been reported.
Case report: Two previously nonalcoholic healthy men suffered from acute ischemic stroke after a single episode of binge drinking. Both patients had one risk factor for stroke (a history of hypertension) and were heterozygous for ALDH2*2. CONCULUSION: The confluence of these factors with stroke has raised the possibility that heavy binge drinking increases the risk of acute stroke in hypertensives with the variant ALDH2*2 gene allele.