Fluorescence sensing of caffeine in aqueous solution with carbazole-based probe and imaging application in live cells

Ajit Kumar Mahapatra; Jagannath Roy; Prithidipa Sahoo; Subhra Kanti Mukhopadhyay; Anindita Roy Mukhopadhyay; Debasish Mandal

doi:10.1016/j.bmcl.2012.07.055

Fluorescence sensing of caffeine in aqueous solution with carbazole-based probe and imaging application in live cells

Bioorg Med Chem Lett. 2012 Sep 1;22(17):5379-83. doi: 10.1016/j.bmcl.2012.07.055. Epub 2012 Jul 21.

Authors

Ajit Kumar Mahapatra¹, Jagannath Roy, Prithidipa Sahoo, Subhra Kanti Mukhopadhyay, Anindita Roy Mukhopadhyay, Debasish Mandal

Affiliation

¹ Department of Chemistry, Bengal Engineering and Science University, Shibpur, Howrah 711103, India. mahapatra574@gmail.com

PMID: 22877628
DOI: 10.1016/j.bmcl.2012.07.055

Abstract

The host-guest interaction of caffeine in aqueous solutions has been achieved by using carbazole based imino-phenol receptors with oxopurines influences their fluorescence properties and can be exploited for 'turn-ON' fluorescence sensing of caffeine. This new fluorescent probe with high sensitivity and selectivity for detection and first time imaging of caffeine in living cells was developed in aqueous media.

Publication types

Evaluation Study
Research Support, Non-U.S. Gov't

MeSH terms

Caffeine / analysis*
Candida albicans / cytology
Carbazoles / chemistry*
Cell Survival
Fluorescent Dyes / chemistry*
Microscopy, Fluorescence / methods
Models, Molecular
Sensitivity and Specificity
Spectrometry, Fluorescence / methods*
Water / chemistry

Substances

Carbazoles
Fluorescent Dyes
Water
carbazole
Caffeine