GOx signaling triggered by aptamer-based ATP detection

Chem Commun (Camb). 2012 Sep 25;48(74):9284-6. doi: 10.1039/c2cc34279k. Epub 2012 Aug 9.

Abstract

Aptamer based ATP binding leads to the release of the co-factor FAD, which acts as a trigger to 'turn-on' the activity of apo-GOx and thus generates a measurable response.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adenosine Triphosphate / metabolism*
  • Aptamers, Nucleotide / metabolism*
  • Biosensing Techniques / methods*
  • Enzymes, Immobilized / chemistry
  • Enzymes, Immobilized / metabolism
  • Flavin-Adenine Dinucleotide / metabolism
  • Glucose Oxidase / chemistry
  • Glucose Oxidase / metabolism*

Substances

  • Aptamers, Nucleotide
  • Enzymes, Immobilized
  • Flavin-Adenine Dinucleotide
  • Adenosine Triphosphate
  • Glucose Oxidase