Passing to the limit 2D-1D in a model for metastatic growth

J Biol Dyn. 2012:6 Suppl 1:19-30. doi: 10.1080/17513758.2011.568071. Epub 2011 Jun 24.

Abstract

We prove the convergence of a family of solutions to a two-dimensional transport equation with a non-local boundary condition modelling the evolution of a population of metastases. We show that when the data of the repartition along the boundary tend to a Dirac mass, then the solution of the associated problem converges and we derive a simple expression for the limit in terms of the solution of a 1D equation. This result permits us to improve the computational time needed to simulate the model.

MeSH terms

  • Cell Proliferation
  • Computer Simulation
  • Humans
  • Models, Biological*
  • Neoplasm Metastasis / pathology*