Echinoclerodane A: a new bioactive clerodane-type diterpenoid from a gorgonian coral Echinomuricea sp

Molecules. 2012 Aug 7;17(8):9443-50. doi: 10.3390/molecules17089443.

Abstract

A new clerodane-type diterpenoid, echinoclerodane A (1), was isolated from a Formosan gorgonian coral Echinomuricea sp. The structure of 1 was elucidated by spectroscopic methods. Echinoclerodane A (1) is the first clerodane-type compound obtained from the marine organisms belonging to the phylum Cnidaria. Echinoclerodane A (1) exhibited moderate cytotoxicity toward MOLT-4, HL-60, DLD-1 and LoVo tumor cells and inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Antibiotics, Antineoplastic / pharmacology
  • Cell Line, Tumor
  • Computer Simulation
  • Diterpenes, Clerodane / chemistry
  • Diterpenes, Clerodane / isolation & purification*
  • Diterpenes, Clerodane / pharmacology
  • Doxorubicin / pharmacology
  • Models, Chemical
  • Models, Molecular
  • Molecular Conformation
  • Neutrophils / drug effects
  • Neutrophils / enzymology
  • Pancreatic Elastase / metabolism
  • Superoxides / metabolism

Substances

  • Antibiotics, Antineoplastic
  • Diterpenes, Clerodane
  • echinoclerodane A
  • Superoxides
  • Doxorubicin
  • Pancreatic Elastase