Abstract
A new clerodane-type diterpenoid, echinoclerodane A (1), was isolated from a Formosan gorgonian coral Echinomuricea sp. The structure of 1 was elucidated by spectroscopic methods. Echinoclerodane A (1) is the first clerodane-type compound obtained from the marine organisms belonging to the phylum Cnidaria. Echinoclerodane A (1) exhibited moderate cytotoxicity toward MOLT-4, HL-60, DLD-1 and LoVo tumor cells and inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthozoa / chemistry*
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Antibiotics, Antineoplastic / pharmacology
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Cell Line, Tumor
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Computer Simulation
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Diterpenes, Clerodane / chemistry
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Diterpenes, Clerodane / isolation & purification*
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Diterpenes, Clerodane / pharmacology
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Doxorubicin / pharmacology
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Models, Chemical
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Models, Molecular
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Molecular Conformation
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Neutrophils / drug effects
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Neutrophils / enzymology
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Pancreatic Elastase / metabolism
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Superoxides / metabolism
Substances
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Antibiotics, Antineoplastic
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Diterpenes, Clerodane
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echinoclerodane A
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Superoxides
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Doxorubicin
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Pancreatic Elastase