The erythrocyte blood groups antigens are associated with risk of certain malignancies though the correlation between blood groups and diseases is still unclear. The investigation is aimed at determining the correlation between benign tumors of the uterus and erythrocyte blood groups alleles and haplotyphes in patients of Adjara Oncology Centre. Blood of 60 women with benign tumors of the uterus and of 60 healthy women of reproductive age were investigated for ABO and Rh system alleles and haplotypes. Immunoserological methods have been used to identify the antigens. The obtained results were statistically processed. The ABO system gene alleles' frequency was computed by the formula proposed by F. Bernstein and used in investigation of three-allele genetic systems. The frequency of Rh-system genes, Rh-haplotypes is computed by the formula proposed by A. E. Mourant. According to ABO systems in women with benign tumors of the uterus high frequencies of p (0,12) and q (0,21) alleles are found. When studying individual alleles of the Rh system in women with benign tumors, high frequency of D was noticed (0.8). In women with benign tumor of the uterus RhD allele frequency is statistically different to healthy women. ABO systems gene alleles' significantly differ in healthy and diseased women. In women with benign tumor of the uterus only three Rh-system haplotypes have been found: CDe, cDe, cde haplotypes.