Abstract
In the present study, we investigated the neuroprotection of simvastatin in PC12 cells following 1-methyl-4-phenylpyridinium ion (MPP+) neurotoxicity. Simvastatin inhibited the decrease of cell viability induced by MPP+ in PC12 cells. The damage of PC12 cells in morphology was alleviated and the apoptotic rates were decreased due to simvatatin pretreatment against MPP+ cytotoxicity. The reactive oxygen species production exposure to MPP+ was inhibited by simvatatin in PC12 cells. So simvastatin may be of therapeutic benefit for PD patients.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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1-Methyl-4-phenylpyridinium / antagonists & inhibitors
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1-Methyl-4-phenylpyridinium / toxicity*
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Animals
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Apoptosis / drug effects*
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Apoptosis / physiology
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Cell Survival / drug effects
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Cell Survival / physiology
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Neuroprotective Agents / pharmacology*
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PC12 Cells
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Rats
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Reactive Oxygen Species / antagonists & inhibitors*
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Reactive Oxygen Species / metabolism
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Simvastatin / pharmacology*
Substances
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Neuroprotective Agents
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Reactive Oxygen Species
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Simvastatin
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1-Methyl-4-phenylpyridinium