Abstract
Histological changes observed under light microscope illustrate follicular degeneration in ovary, vacuolation and mild disorganization of uterus on treatment with graded doses of alcohol seed extract of Caesalpinia bonducella. There was a significant decrease (p≤0.05) in duration of estrous cycle and mean ovarian weight. However, there were no uniform variations in mean uterine weight, serum estradiol and progesterone level. The results suggest that alcohol seed extract of C. bonducella has antiestrogenic property, possibly acting via inhibition of estrogen secretion.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Caesalpinia* / chemistry
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Dose-Response Relationship, Drug
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Estradiol / blood
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Estrogen Receptor Modulators / chemistry
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Estrogen Receptor Modulators / isolation & purification
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Estrogen Receptor Modulators / pharmacology*
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Estrous Cycle / blood
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Estrous Cycle / drug effects
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Female
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Organ Size
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Ovary / drug effects*
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Ovary / metabolism
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Ovary / pathology
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Progesterone / blood
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Rats
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Rats, Wistar
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Seeds
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Uterus / drug effects*
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Uterus / metabolism
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Uterus / pathology
Substances
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Estrogen Receptor Modulators
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Plant Extracts
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Progesterone
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Estradiol