Abstract
Two new succinic acid derivatives, xylacinic acids A (1) and B (2), along with seven known compounds, including one succinic acid derivative (3), three mellein derivatives (4-6), cytochalasin D (7), 2-chloro-5-methoxy-3-methylcyclohexa-2,5-diene-1,4-dione (8) and isosclerone (9), were isolated from the mangrove-derived fungus Xylaria cubensis PSU-MA34. Their structures were established by spectroscopic evidence. They were evaluated for cytotoxicity against KB cells and antibacterial activity against Staphylococcus aureus ATCC 25923 and methicillin-resistant S. aureus.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Humans
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Methicillin-Resistant Staphylococcus aureus / drug effects
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Methicillin-Resistant Staphylococcus aureus / growth & development
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Microbial Sensitivity Tests
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Molecular Structure
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Rhizophoraceae / microbiology*
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Spectrophotometry, Ultraviolet
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Spectroscopy, Fourier Transform Infrared
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Staphylococcus aureus / drug effects
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Staphylococcus aureus / growth & development
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Xylariales / isolation & purification
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Xylariales / metabolism*
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents