ABO blood groups antigens have biological and clinical significance. The ABO blood groups antigens has been associated with many diseases, though the explanation between ABO blood groups and disease is still unclear. The aim of this study is to investigate the presence of a possible association between benign tumors of the utesus with blood ABO, RhD, Kell and MN groups in women in reproductive periods. In diseased population (60 subject) was investigated for Erythrocyte phenotypic groups antigens. Immunoserological methods have been used to identify the antigens. The obtained results were statistically processed. High frequencies of A (43,3±3,2%), D(91,6±3,5%) and Kell (+) (26.66±5.7 %) antigens were found in diseased of benign tumors of uterus comparison with donor. The researches shows, that is increased risk of disease development in carriers of these phenotypes. In summary, according our research we've thought, that blood groups may be a marker for bening tomors of the uterus. Based on these data, these could be used as prognostic factor for bening tomors of the uterus. The study of Erythrocyte group antigens in diseased we may to identify "high risk" individuals, that help to find ways, which help to control of disease.