Prototheca wickerhamii as a cause of neuroinfection in a child with congenital hydrocephalus. First case of human protothecosis in Poland

Diagn Microbiol Infect Dis. 2012 Oct;74(2):186-9. doi: 10.1016/j.diagmicrobio.2012.06.015. Epub 2012 Aug 2.

Abstract

This report describes a rare case of neuroinfection due to Prototheca wickerhamii in a child with severe, congenital hydrocephalus. The infection resolved completely after the patient was treated with oral ketoconazole, followed by intravenous fluconazole and amphotericin B. A probable source of infection was contamination during ventriculoperitoneal drain care procedures.

Publication types

  • Case Reports

MeSH terms

  • Amphotericin B / administration & dosage
  • Antifungal Agents / administration & dosage
  • DNA, Plant / chemistry
  • DNA, Plant / genetics
  • Fluconazole / administration & dosage
  • Head / diagnostic imaging
  • Humans
  • Hydrocephalus / complications*
  • Infant
  • Ketoconazole / administration & dosage
  • Male
  • Meningoencephalitis / diagnosis*
  • Meningoencephalitis / microbiology*
  • Meningoencephalitis / pathology
  • Microscopy, Electron
  • Molecular Sequence Data
  • Poland
  • Prototheca / classification
  • Prototheca / genetics
  • Prototheca / isolation & purification*
  • Sequence Analysis, DNA
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Ventriculoperitoneal Shunt / adverse effects

Substances

  • Antifungal Agents
  • DNA, Plant
  • Amphotericin B
  • Fluconazole
  • Ketoconazole

Associated data

  • GENBANK/JX256253