Abstract
This report describes a rare case of neuroinfection due to Prototheca wickerhamii in a child with severe, congenital hydrocephalus. The infection resolved completely after the patient was treated with oral ketoconazole, followed by intravenous fluconazole and amphotericin B. A probable source of infection was contamination during ventriculoperitoneal drain care procedures.
Copyright © 2012 Elsevier Inc. All rights reserved.
MeSH terms
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Amphotericin B / administration & dosage
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Antifungal Agents / administration & dosage
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DNA, Plant / chemistry
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DNA, Plant / genetics
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Fluconazole / administration & dosage
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Head / diagnostic imaging
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Humans
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Hydrocephalus / complications*
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Infant
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Ketoconazole / administration & dosage
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Male
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Meningoencephalitis / diagnosis*
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Meningoencephalitis / microbiology*
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Meningoencephalitis / pathology
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Microscopy, Electron
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Molecular Sequence Data
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Poland
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Prototheca / classification
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Prototheca / genetics
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Prototheca / isolation & purification*
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Sequence Analysis, DNA
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Tomography, X-Ray Computed
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Treatment Outcome
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Ventriculoperitoneal Shunt / adverse effects
Substances
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Antifungal Agents
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DNA, Plant
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Amphotericin B
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Fluconazole
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Ketoconazole